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This mediator release elevates vascular permeability, facilitating protein extravasation and cellular infiltration into lung tissue, ultimately triggering pulmonary edema

Ketamine was initially introduced as an anesthetic and analgesic for medical applications ( 5.1 Pharmacological effects 5.1.1 NMDAR antagonism Ketamine exerts its primary effects by acting as a noncompetitive antagonist of NMDARs and reducing glutamate-mediated excitatory neurotransmission (Zhou and Tajima, 2023)

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Cancer , 115 , 741-751, doi: Das, F., Dey, N., Bera, A., Kasinath, B