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Lintner K, Peschard O

"Total mass may come down, but you'll probably lose as much muscle as you will fat, so whilst you might get a very temporary, and this is only speculative, increase in watts per kilo that will shortly be followed by a big drop in total capacity to produce watts," said Impey

That said, there are two scenarios where degraded medication could cause issues

Int J Biochem Cell Biol 36:18611867 Jones LL, McDonald DA, Borum PR (2010) Acylcarnitines: role in brain

Baseline thyroid function assessment is advisable before initiating tirzepatide in patients with known or suspected Hashimoto's thyroiditis