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2012;97(4):E632-636

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Regulatory Expectations for Forced Degradation Studies Regulatory agencies expect forced degradation studies to be scientifically justified, comprehensive, and product-specific, rather than generic stress testing exercises

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These features overlap with the well-known ABCDE warning signs of skin melanoma: A symmetry B order irregularity C olour variegation D iameter larger than 6 mm (often) E volving size, shape or surface What it feels like Most early oral melanomas are painless

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