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Drinking calories: Juice, sweet coffee drinks, and alcohol add calories without triggering the satiety signals tirzepatide amplifies

Months 4 to 6: Fat loss accelerates, and many patients experience enhanced muscle definition and metabolic improvements

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SURMOUNT-2 (tirzepatide in type 2 diabetes with obesity) reported similar constipation rates and confirmed that GI events clustered around dose-escalation windows

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