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24 Secondly, activated Akt phosphorylates forkhead box O1 (FOXO1), a transcription factor upregulating gluconeogenesis rate-limiting enzyme such as phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), and translocate it from nucleus to cytoplasm, which inactivate its transcriptional activity, thus inhibiting gluconeogenesis

Jimnez-Snchez et al., 2016)

Severe gallbladder disease, uncontrolled severe depression or suicidal ideation, and advanced diabetic retinopathy also require careful evaluation or avoidance

One randomized control trial with 439 volunteers found slight increases in IGF-1 among overweight and obese women who lost weight by restricting calories (29)

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