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Finally, group 10 acted as a vehicle control for Dihexa in group 8 and received local MSC and DMSO via hydrogel, and intravenous injection of MSC, and an injection into the gastrocnemius muscle with MSC and DMSO [2]

Scopolamine hydrobromide at a dose of 70 nmol was administered to induce memory deficits reminiscent of Alzheimers disease

Lyophilized peptide should be stored at -20C (freezer), and the reconstituted peptide solution at 4C (refrigerated)

Group 1 was a vehicle control that received an intravenous injection of saline

Previous AngIV analogs, while showing promise in animal models of dementia, were hindered by poor metabolic stability indicated by a short half-life, and an inability to cross the BBB due to their peptide nature