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Whilst certain studies do hint at possible direct effects of thiazide, thiazide-like and loop diuretics on glucose homeostasis, and that its control is apparently beneficial for some aspects of the MetS, it is clear that additional research is necessary to fully understand the specific mechanisms involved and the potential clinical implications that they may have in hypertensive individuals with chronic metabolic conditions

doi: 10.1176/appi.ajp.2014.13101407

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Research shows these medications improve blood glucose control, reduce cardiovascular risk, and support sustainable metabolic improvements in patients with chronic weight-related conditions