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This results in a decrease in mitochondrial transcription factor TFAM and impaired mitochondrial function, which ultimately leads to increased vulnerability to oxidative stress and neuronal deterioration (Sharma A

doi: 10.1186/s12894-023-01353-z 62 TehranianCFankhauserLHarterPNRatcliffeCZeinerPSMessmerJMet al

Asia Pac Psychiatry 11:e12340 Aghaei S, Mazharinia N, Jafari P, Abbasfard Z (2006) The Persian version of the Cardiff acne disability index

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Beyond sleep, researchers have studied DSIP for its effects on stress hormone regulation specifically its ability to modulate ACTH and cortisol secretion making it of interest in HPA axis research