A great experience all around. Jessica Pfeffer, Miami, FL Everything was amazing Anthony was on time and what started as 2 IV therapies ended in 4 our neighbors joined us thank you so much ready with the pre party and b12 add on Every detail was thoughtfully executed
H., Gallagher, B
doi: 10.1094/MPMI-12-12-0286-R 2 AmariK.Daz-VivancosP.PallsV.Snchez-PinaM
Key pathophysiologic mechanisms include: Mucosal barrier dysfunction: Impaired epithelial tight junctions allow bacterial translocation, triggering innate immune activation T-helper cell dysregulation: Predominantly Th1 and Th17 pathways drive chronic inflammation via TNF-, IL-12, IL-23 the basis for biologic therapy targets Transmural inflammation: Unlike UC (mucosal only), CD involves all layers: mucosa submucosa muscularis propria serosa Granuloma formation: Non-caseating granulomas are pathognomonic but present in only ~3050% of biopsies Fibrosis and stricture: Chronic inflammation activates myofibroblasts collagen deposition luminal narrowing obstructive symptoms Fistula formation: Transmural ulcers penetrate serosa form sinus tracts connect to adjacent bowel, bladder, vagina, or skin 7
(PubMed) Stone CA, Kawai K, Kupka R, Fawzi WW
