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Within the ARC, two primary, functionally antagonistic neuronal populations serve as first-order neurons: the anorexigenic pro-opiomelanocortin (POMC)-expressing neurons and the orexigenic agouti-related protein (AgRP)/neuropeptide Y (NPY)-expressing neurons [6]

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They serve as signaling molecules throughout the body, directing cellular behavior, modulating inflammation, and triggering growth and repair processes

Those are natural precursors to natural GLP-1 hormones, Zammer said