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The seven-amino-acid cyclic structure of [Melanotan 2]( creates conformational rigidity that slows enzymatic cleavage, while Melanotan-1s linear 13-amino-acid chain is more vulnerable to peptide bond hydrolysis over time

10.1111/1541-4337.12734 [DOI] [PubMed] [Google Scholar] Janik E, Niemcewicz M, Ceremuga M, Stela M, Saluk-Bijak J, Siadkowski A, Bijak M (2020) Molecular Aspects of MycotoxinsA Serious Problem for Human Health

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Unlike many bioactive compounds that occur naturally in significant quantities, BPC-157 is synthesized from a larger protein found in gastric secretions

(PubMed) Carlson SE, Cooke RJ, Werkman SH, Tolley EA