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These uses may have the backing of plausible mechanistic rationales, but none possess the robust clinical validation I would want to see in a proven protocol

Tesofensine is particularly useful for patients experiencing metabolic slowdown or those at high risk of regaining weight

Contraindications include personal/family history of medullary thyroid carcinoma and multiple endocrine neoplasia type 2

Pla2g6 / mice treated with 0.5 g/g semaglutide did not show a significant deficit in rotarod performance compared to wild-type controls at any time point measured

Statements Author contributions JN: Conceptualization, Validation, Visualization, Writing original draft, Writing review & editing