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This review aims to provide a brief overview of relevant concepts in disease modification, pathophysiological mechanisms in PD, the most relevant disease-modifying candidates so far, and challenges in neuroprotection in manifest PD, as well as to discuss strategies to address those

This meta-analysis aims to evaluate whether the effects of SGLT-2i or GLP-1 RAs on cardiovascular outcomes are consistent with and without baseline metformin use

Pernicious anaemia is associated with osteoporosis

In addition, lipophagy, in which lipid droplets are eliminated, and clockophagy, which is based on the circadian rhythm protein ARNTL, play potential roles in ferroptosis and are associated to some degree with mitophagy [290, 291]

Last reviewed: June 2026 Retatrutides trial numbers have generated more interest than any metabolic compound in recent memory