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GLP-1 receptor agonists trigger nausea through activation of central GLP-1 receptors in the brainstem, specifically in the area postrema and the nucleus of the solitary tract

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Beyond this threshold, you're primarily increasing side effect risk rather than accelerating results

It has also been suggested that the combination of folate, vitamin B12, and vitamin B6 may improve methylation, increase transsulfuration, and possibly reduce stress

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