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In some embodiments, the otic formulation or composition comprises about 0.08% by weight of the poloxamer

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Additionally, acetyl-L-carnitine has been found to reverse age-related declines in carnitine palmitoyltransferase 1 activity in specific heart mitochondria, enhancing their ability to process fatty acids and maintain energy production.[19] Such supplementation may help sustain energy levels, muscle mass, and overall vitality, offering a potential strategy to counteract the effects of aging.[20] More research is needed to confirm whether or not such benefits would apply to humans