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Here we demonstrate that mice treated with either semaglutide or GLP-1MK-801 exhibit a similar yet transient effect on exercise avoidance (Extended Data Fig

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Weight regain is common after stopping weight-management medication

Keeping up with the Joneses mentality creates comparison pressures that intensify weight struggles beyond simple biological challenges

The appetite suppression mechanism works through both central nervous system pathways and peripheral gut signaling, creating a comprehensive effect that diet alone cannot replicate