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Truveta Research was able to use real-world data to explore a larger, more diverse patient population more than 10 times the size of the SURMOUNT-5 study (8,823 patients with overweight or obesity and without type 2 diabetes vs

It is important to note that: Most clinical trials have follow-up periods of 25 years, which may not capture very long-term cancer development Patients with type 2 diabetes and obesity have baseline elevated cancer risks due to metabolic factors Post-marketing surveillance continues to monitor for rare or delayed adverse events The Medicines and Healthcare products Regulatory Agency (MHRA) and the European Medicines Agency (EMA) continue to review safety data as part of ongoing pharmacovigilance activities, and no major cancer-related safety signals have emerged that would warrant withdrawal or significant restriction of these medicines

Human and rat results should therefore be shown separately and should not be combined into one cross-species ranking

Chest pressure or pain, especially with sweating, nausea, or pain spreading to the arm, jaw, back, or shoulder

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