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For tumour xenograft models, 1 10 6 HCC-1806 cells or 5 10 6 PC3 cells were injected into the right fourth mammary fat pad or hind flank of athymic nude NU/J mice (The Jackson Laboratory, 002019) in 100 l sterile PBS or a 1:1 mixture of cell suspension in PBS and Matrigel (Corning, 356237) using a 29-gauge 1 ml insulin syringe

Other Factors In some cases, tooth discoloration stems from excessive fluoride exposure during childhood, certain medications like antibiotics, genetic factors influencing enamel strength, dental trauma, or existing dental work like silver fillings

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After the Collaboration Agreement became effective on July 1, 2025, we and Novo commenced four simultaneous research and development programs (each an R&D Program) with each pursuing one or more Collaboration Targets from discovery through development candidate selection

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