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2003 Jun-Aug;24(3-4):233-40

Clinical implications of the pharmacokinetics of crizotinib in populations of patients with non-small cell lung cancer

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This D-retro-inverso configuration preserves the three-dimensional side-chain topology of the original FOXO4 sequence maintaining functional mimicry of the FOXO4 forkhead domains interaction surface with p53 while conferring exceptional proteolytic stability compared to the native L-amino acid sequence