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Increasing age and higher BMI are strongly associated with an elevated risk of T2D, while smoking exacerbates the condition by contributing to insulin resistance and impaired glucose metabolism

It is also contraindicated in patients with a history of pancreatitis or gastrointestinal issues since it increases gastrointestinal emptying time which can intensify symptoms

Taking the capsule with a small amount of water and maintaining the empty stomach recommendation usually minimizes this effect