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The effects of GLP-1 RA on SMI In three studies, 317 participants showed changes in SMI, with 158 receiving GLP-1 RA and 199 in the control group

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Yet hormonal changes can be complex: Men who begin GLP-1 therapy may initially experience a small dip in testosterone as body fat decreases, since adipose tissue helps regulate conversion of testosterone to estrogen

Impact on the Brains Reward System: GLP-1 receptor agonists, like Ozempic, interact with the brains reward system, which regulates appetite and pleasure