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This is well illustrated by the velocity equation for the CBS reaction, the first step in the transsulfuration pathway: The first factor is simply Michaelis-Menten kinetics for the CBS reaction that uses homocysteine (Hcy) and serine (Ser) as substrates

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Insufficient intake of magnesium, loss of magnesium through the digestive system and kidneys, and redistribution of magnesium from the extracellular space to the intracellular space are the main causes of magnesium deficiency (182)

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