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Both pathways, cAMP PKA and GHS-R1a, converge on the pituitary gland

Excess iron can disrupt testosterone production, so giving blood prevents a buildup

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Available as a weekly injection or a daily oral pill, semaglutide works by acting like the hormone GLP-1, reducing appetite and promoting sustained weight loss

| Milestone | Ozempic (Semaglutide) | Trulicity (Dulaglutide) | |---|---|---| | Starting dose | 0.25 mg/week | 0.75 mg/week | | First escalation | 0.5 mg at week 4 | 1.5 mg at week 4 | | Second escalation | 1.0 mg at week 8 | 3.0 mg at week 24 | | Maximum approved dose (T2D) | 2.0 mg/week | 4.5 mg/week | | Minimum effective dose | 0.5 mg/week | 0.75 mg/week | Semaglutide reaches its minimum effective dose faster