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Description

This work was supported by grants from the Chung Shan Medical University Hospital (CSH-2022-A-004)

AANAT is the rate-limiting enzyme of melatonin because it controls the circadian rhythm of melatonin production via the pineal gland

To demonstrate its relevance in vivo , mice were administrated with AAV8-shRNA-LRP1 (KD) and AAV8-scramble-LRP1 (scr) intravenously, accompanied by CCl 4 -induced liver fibrosis (Fig