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Phase 2 trials showed average weight loss of 24% at the highest dose over 48 weeks Significant improvements in blood glucose control and insulin sensitivity were observed Similar medications have shown PCOS-specific benefits including improved menstrual regularity Gastrointestinal side effects were most common but typically improved with continued use Specific PCOS trials are ongoing and will provide direct evidence for this population Comparing Retatrutide to Current PCOS Treatments Understanding how retatrutide fits into the current landscape of PCOS treatments helps frame its potential role in future management approaches

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Starting Doses Most protocols recommend starting with lower doses and gradually increasing

The Medicaid program now in Pennsylvania only covers GLP-1 drugs for people with diabetes or those who meet a narrower set of criteria, such as those with sleep apnea and a body mass index of at least 35

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