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ER/ER ratio and aromatase expression levels as well as 2-hydroxyestrone:16-hydroxyestrone ratios are becoming used as biomarkers to direct phytoestrogen or DIM (diindolylmethane) supplementation, whereas the NF-B, STAT3 and PI3K/Akt phosphorylation status potentially indicating curcumin, resveratrol or polyphenols use for chemosensitizing
2022;10:899095.35646909 [Google Scholar] 34.Zhang J, Lu T, Xiao J, Du C, Chen H, Li R, Sui X, Pan Z, Xiao C, Zhao X, et al
GHK-Cu, by contrast, appears to act more directly on fibroblast signaling and collagen gene transcription, with VEGF upregulation occurring as part of a broader tissue remodeling response
doi: 10.1016/j.fbio.2021.101432