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Respiratory depression is the chief risk for elderly patients treated with opioids, and has occurred after large initial doses were administered to patients who were not opioid-tolerant or when opioids were co-administered with other agents that depress respiration

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The identification of high affinity GSH transporter in yeast ( Arabidopsis possess nine homologs of the yeast HGT1 (Zhang et al., 2004), the affinity and specificity was not as high as expected for the high flux of GSH within plant cells