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MOTS-c and 5-Amino-1MQ meet that standard because 5-Amino-1MQ directly addresses the NAD+ limitation that would otherwise cap MOTS-c's efficacy

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It was first isolated and characterised by Professor Predrag Sikiric and his research group at the University of Zagreb in the early 1990s, with the foundational paper published in the Journal of Physiology (Paris) in 1993