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Acknowledgements This study was supported by Center for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital for facilities, and with the grant support of the Ministry of Science and Technology, TAIWAN, under grants nos 104-2221-E-182-034, 104-2314-B-039-058,104-2314-B-039-058, 105-2221-E-182-022, 105-2221-E-182-022, 105-2923-B-002-001-MY3, Taiwan Ministry of Health and Welfare Clinical Trial Center (MOHW107-TDU-B-212-113004), and by Chang Gung Memorial Hospital, TAIWAN, under grants nos CIRPD2E0051-53, CMRPD2D0111-13, and CMRPG3D1061-3

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Loren Pickart, who noticed that when plasma from young individuals was added to the liver tissue of older individuals, the older tissue would produce proteins more characteristic of younger individuals