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Here, CHAC1 is upregulated by the ATF4-CHOP cascade and leads to cell death by perturbation of the redox homeostasis through changes in the ROS levels (Wang et al., 2022)

The mechanisms allowing for this change between the 2 metabolic profiles will have to be elucidated in future studies

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doi: 10.1111/cen.2015.82.issue-6 144 MashaAManieriCDinataleSBrunoGGhigoEMartinaV

While probiotic/prebiotic supplementation does not affect thyroid hormone levels, it may modestly reduce TRAb levels in Graves disease patients (Zawadzka et al., 2023