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Chronic studies in rats given 200 mg/kg body weight per day for 104 weeks, dogs given 20 mg/kg PO x 84 days, cats given 40-65 mg/kg for 118 days did not produce any signs of toxicity (blood testing, liver histology)

Its a lock-and-key situation where caffeine is the wrong key that jams the lock

There is also some evidence that cytosolic calcium may be increased via the cAMP second messenger 27

However, it is not a "standard" test included in a typical annual physical or a routine blood panel at a walk-in clinic

While exercise and strength training can help tone the underlying muscles in these areas, they may not be enough to get rid of the excess skin