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Risk and Handling Precautions Risk Tier: MODERATE This rating reflects both peptides' bioactive activity at angiogenic and cytoskeletal signaling pathways in preclinical models, the absence of established human safety profiles for either compound, and the additional handling considerations specific to intranasal formulations

Acknowledgements This study has been delivered through the National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre (BRC)

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