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Pep-21 treatment specifically silenced target miR-21 in B16 melanoma cells and M2 macrophages, reducing tumor cell migration and inhibiting tumor progression

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Moreover, excess iron could promote the formation of reactive oxygen species (ROS), which can lead to oxidative stress and DNA damage, with cytokine-regulated inflammatory pathways and a central contribution from innate immune cells in the tumor microenvironment (360, 361)

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