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Some patients might experience mild symptoms, while others may need to work closely with their healthcare provider to find the right management strategy

The vulnerability is the tryptophan in the core motif

In previous studies, we verified that PKU patients (treated with a protein-restricted diet supplemented with a special formula not containing l-carnitine and selenium) presented high lipid and protein oxidative damage as well as a reduction of antioxidants when compared to the healthy individuals

Both of these numbers come from the 1989 study that used rabbit ears

Yet even a DPP-4-resistant peptide is small enough to be filtered by the glomeruli in the kidneys into the urine