Accompanying gastrointestinal symptoms that suggest more serious conditions require medical assessment
Here, it tweaks the balance of neural signals, releases satiety signals, suppresses hunger, cuts down on the desire to eat, controls calorie intake from the source, and helps stabilize blood glucose in a reasonable range
When transit time slows (reduced intestinal motility), more water is absorbed from your stool, making it harder, drier, and tougher to pass
As for mortality, both SGLT-2 inhibitors and GLP-1RA are similar in reducing both total and CV deaths, but SGLT-2 inhibitors only are superior to DPP-4 inhibitors for both deaths, whereas GLP-1RA are superior to DPP-4 inhibitors for total death, but equal for CV death
doi: 10.1056/NEJMoa2107519